![](https://github.com/nlmixr2/nlmixr2est/raw/HEAD/logo.png)
nlmixr2est - Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
Last updated 10 days ago
6 stars 3.44 score 66 dependencies 8 dependents![](https://github.com/nlmixr2/nlmixr2/raw/HEAD/logo.png)
nlmixr2 - Nonlinear Mixed Effects Models in Population PK/PD
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
Last updated 10 days ago
37 stars 3.43 score 146 dependencies 2 dependentsrxode2parse - Parsing and Code Generation Functions for 'rxode2'
Provides the parsing needed for 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>). It also provides the 'stan' based advan linear compartment model solutions with gradients (Carpenter et al (2015), <doi:10.48550/arXiv.1509.07164>) needed in 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This split will reduce computational burden of recompiling 'rxode2'.
Last updated 10 days ago
1 stars 3.40 score 22 dependencies 15 dependents![](https://github.com/nlmixr2/lotri/raw/HEAD/man/figures/logo.png)
lotri - A Simple Way to Specify Symmetric, Block Diagonal Matrices
Provides a simple mechanism to specify a symmetric block diagonal matrices (often used for covariance matrices). This is based on the domain specific language implemented in 'nlmixr2' but expanded to create matrices in R generally instead of specifying parts of matrices to estimate.
Last updated 1 months ago
4 stars 3.22 score 1 dependencies 15 dependents![](https://github.com/nlmixr2/rxode2random/raw/HEAD/logo.png)
rxode2random - Random Number Generation Functions for 'rxode2'
Provides the random number generation (in parallel) needed for 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This split will reduce computational burden of recompiling 'rxode2'.
Last updated 10 days ago
1 stars 3.20 score 26 dependencies 14 dependentsrxode2et - Event Table Functions for 'rxode2'
Provides the event table and support functions needed for 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This split will reduce computational burden of recompiling 'rxode2'.
Last updated 10 days ago
1 stars 3.13 score 29 dependencies 13 dependentsrxode2ll - Log-Likelihood Functions for 'rxode2'
Provides the log-likelihoods with gradients from 'stan' (Carpenter et al (2015), <arXiv:1509.07164>) needed for generalized log-likelihood estimation in 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This is split of to reduce computational burden of recompiling 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) which runs the 'nlmixr2' models during estimation.
Last updated 1 years ago
2 stars 2.87 score 7 dependencies 13 dependentsnlmixr2data - Nonlinear Mixed Effects Models in Population PK/PD, Data
Datasets for 'nlmixr2' and 'rxode2'. 'nlmixr2' is used for fitting and comparing nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
Last updated 6 months ago
3 stars 2.61 score 0 dependencies 9 dependents![](https://github.com/nlmixr2/nlmixr2extra/raw/HEAD/logo.png)
nlmixr2extra - Nonlinear Mixed Effects Models in Population PK/PD, Extra Support Functions
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.
Last updated 10 days ago
3 stars 2.15 score 77 dependencies 4 dependentsbabelmixr2 - Use 'nlmixr2' to Interact with Open Source and Commercial Software
Run other estimation and simulation software via the 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>) interface including 'PKNCA', 'NONMEM' and 'Monolix'. While not required, you can get/install the 'lixoftConnectors' package in the 'Monolix' installation, as described at the following url <https://monolix.lixoft.com/monolix-api/lixoftconnectors_installation/>. When 'lixoftConnectors' is available, 'Monolix' can be run directly instead of setting up command line usage.
Last updated 9 days ago
monolixnonmempharmacometrics
7 stars 1.87 score 153 dependencies![](https://github.com/nlmixr2/nlmixr2plot/raw/HEAD/logo.png)
nlmixr2plot - Nonlinear Mixed Effects Models in Population PK/PD, Plot Functions
Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for 'ggplot2' plotting methods for 'nlmixr2' objects.
Last updated 10 days ago
2 stars 1.86 score 147 dependencies 3 dependentsnlmixr2lib - A Model Library for 'nlmixr2'
A model library for 'nlmixr2'. The models include (and plan to include) pharmacokinetic, pharmacodynamic, and disease models used in pharmacometrics. Where applicable, references for each model are included in the meta-data for each individual model. The package also includes model composition and modification functions to make model updates easier.
Last updated 8 days ago
5 stars 1.71 score 67 dependenciesnlmixr2rpt - Templated Word and PowerPoint Reporting of 'nlmixr2' Fitting Results
This allows you to generate reporting workflows around 'nlmixr2' analyses with outputs in Word and PowerPoint. You can specify figures, tables and report structure in a user-definable 'YAML' file. Also you can use the internal functions to access the figures and tables to allow their including in other outputs (e.g. R Markdown).
Last updated 3 days ago
2 stars 1.02 score 196 dependenciesxpose.nlmixr2 - Graphical Diagnostics for Pharmacometric Models: Extension to 'nlmixr2'
Extension to 'xpose' to support 'nlmixr2'. Provides functions to import 'nlmixr2' fit data into an 'xpose' data object, allowing the use of 'xpose' for 'nlmixr2' model diagnostics.
Last updated 2 years ago
1 stars 0.61 score 99 dependencies 1 dependentsnlmixr2targets - Targets for 'nlmixr2' Pipelines
'nlmixr2' often has long runtimes. A pipeline toolkit tailored to 'nlmixr2' workflows leverages 'targets' and 'nlmixr2' to ease reproducible workflows. 'nlmixr2targets' ensures minimal rework in model development with 'nlmixr2' and 'targets' by simplifying and standardizing models and datasets.
Last updated 4 months ago
0.36 score 77 dependencies