Package: nlmixr2extra 2.0.10

Matthew Fidler

nlmixr2extra: Nonlinear Mixed Effects Models in Population PK/PD, Extra Support Functions

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.

Authors:Matthew Fidler [aut, cre], Vipul Mann [aut], Vishal Sarsani [aut], Christian Bartels [ctb], Bill Denney [aut]

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nlmixr2extra.pdf |nlmixr2extra.html✨
nlmixr2extra/json (API)
NEWS

# Install 'nlmixr2extra' in R:
install.packages('nlmixr2extra', repos = c('https://nlmixr2.r-universe.dev', 'https://cloud.r-project.org'))

Peer review:

Bug tracker:https://github.com/nlmixr2/nlmixr2extra/issues

Uses libs:
  • openblas– Optimized BLAS
  • c++– GNU Standard C++ Library v3
Datasets:
  • theoFitOde - Example single dose Theophylline ODE model

On CRAN:

25 exports 3 stars 2.15 score 77 dependencies 4 dependents 1.2k downloads

Last updated 10 days agofrom:ae95eee93c

Exports:adaptivelassoCoefficientsaddCatCovariatesaddorremoveCovariateadjustedlassoCoefficientsbackwardSearchbootplotbootstrapFitbuildcovInfobuildupatedUIcovarSearchAutofoldgenforwardSearchhorseshoeSummardfiniknit_printlassoCoefficientslassoSummardfmodelnlmixrnlmixr2nlmixrWithTimingnormalizedDataoptimUnisamplingpreconditionFitregularmodel

Dependencies:backportsBHcachemcheckmateclicolorspacecommonmarkcrayoncurldata.tabledigestdparserevaluatefansifarverfastmapggplot2ggtextgluegridtextgtablehighrinlineisobandjpegknitrlabelinglatticelazyevallbfgsb3clifecyclelotrimagrittrmarkdownMASSMatrixmemoisemgcvminqamunselln1qn1nlmenlmixr2datanlmixr2estnumDerivpillarpkgconfigpngPreciseSumsqsR6RApiSerializeRColorBrewerRcppRcppArmadilloRcppEigenRcppParallelrexrlangrxode2rxode2llscalessitmoStanHeadersstringfishstringistringrsymenginesystibbleutf8vctrsviridisLitewithrxfunxml2yaml