Package 'rxode2ll'

Title: Log-Likelihood Functions for 'rxode2'
Description: Provides the log-likelihoods with gradients from 'stan' (Carpenter et al (2015), <doi:10.48550/arXiv.1509.07164>) needed for generalized log-likelihood estimation in 'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>). This is split of to reduce computational burden of recompiling 'rxode2' (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) which runs the 'nlmixr2' models during estimation.
Authors: Matthew L. Fidler [aut, cre] (ORCID: <https://orcid.org/0000-0001-8538-6691>)
Maintainer: Matthew L. Fidler <[email protected]>
License: GPL (>= 3)
Version: 2.0.14
Built: 2026-06-02 06:21:33 UTC
Source: https://github.com/nlmixr2/rxode2ll

Help Index

Calculate the log likelihood of the binomial function (and its derivatives)

Description

Calculate the log likelihood of the binomial function (and its derivatives)

Usage

llikBeta(x, shape1, shape2, full = FALSE)

Arguments

x

Observation
shape1, shape2

non-negative parameters of the Beta distribution.
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dShape1 and dShape2 that has the derivatives with respect to the parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

x <- seq(1e-4, 1 - 1e-4, length.out = 21)

llikBeta(x, 0.5, 0.5)

llikBeta(x, 1, 3, TRUE)

Calculate the log likelihood of the binomial function (and its derivatives)

Description

Calculate the log likelihood of the binomial function (and its derivatives)

Usage

llikBinom(x, size, prob, full = FALSE)

Arguments

x

Number of successes
size

Size of trial
prob

probability of success
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the pdf value of with dProb that has the derivatives with respect to the parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikBinom(46:54, 100, 0.5)

llikBinom(46:54, 100, 0.5, TRUE)

log likelihood of Cauchy distribution and it's derivatives (from stan)

Description

log likelihood of Cauchy distribution and it's derivatives (from stan)

Usage

llikCauchy(x, location = 0, scale = 1, full = FALSE)

Arguments

x

Observation
location, scale

location and scale parameters.
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dLocation and dScale that has the derivatives with respect to the parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

x <- seq(-3, 3, length.out = 21)

llikCauchy(x, 0, 1)

llikCauchy(x, 3, 1, full=TRUE)

log likelihood and derivatives for chi-squared distribution

Description

log likelihood and derivatives for chi-squared distribution

Usage

llikChisq(x, df, full = FALSE)

Arguments

x

variable that is distributed by chi-squared distribution
df

degrees of freedom (non-negative, but can be non-integer).
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dDf that has the derivatives with respect to the df parameter the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikChisq(1, df = 1:3, full=TRUE)

llikChisq(1, df = 6:9)

log likelihood and derivatives for exponential distribution

Description

log likelihood and derivatives for exponential distribution

Usage

llikExp(x, rate, full = FALSE)

Arguments

x

variable that is distributed by exponential distribution
rate

vector of rates.
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dRate that has the derivatives with respect to the rate parameter the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikExp(1, 1:3)

llikExp(1, 1:3, full=TRUE)

log likelihood and derivatives for F distribution

Description

log likelihood and derivatives for F distribution

Usage

llikF(x, df1, df2, full = FALSE)

Arguments

x

variable that is distributed by f distribution
df1, df2

degrees of freedom. Inf is allowed.
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dDf1 and dDf2 that has the derivatives with respect to the df1/df2 parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

x <- seq(0.001, 5, length.out = 100)

llikF(x^2, 1, 5)

log likelihood and derivatives for Gamma distribution

Description

log likelihood and derivatives for Gamma distribution

Usage

llikGamma(x, shape, rate, full = FALSE)

Arguments

x

variable that is distributed by gamma distribution
shape

this is the distribution's shape parameter. Must be positive.
rate

this is the distribution's rate parameters. Must be positive.
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dProb that has the derivatives with respect to the prob parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikGamma(1, 1, 10)

log likelihood and derivatives for Geom distribution

Description

log likelihood and derivatives for Geom distribution

Usage

llikGeom(x, prob, full = FALSE)

Arguments

x

variable distributed by a geom distribution
prob

probability of success in each trial. 0 < prob <= 1.
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dProb that has the derivatives with respect to the prob parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikGeom(1:10, 0.2)

Calculate the log likelihood of the negative binomial function (and its derivatives)

Description

Calculate the log likelihood of the negative binomial function (and its derivatives)

Usage

llikNbinom(x, size, prob, full = FALSE)

Arguments

x

Number of successes
size

Size of trial
prob

probability of success
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the pdf value of with dProb that has the derivatives with respect to the parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikNbinom(46:54, 100, 0.5)

llikNbinom(46:54, 100, 0.5, TRUE)

Calculate the log likelihood of the negative binomial function (and its derivatives)

Description

Calculate the log likelihood of the negative binomial function (and its derivatives)

Usage

llikNbinomMu(x, size, mu, full = FALSE)

Arguments

x

Number of successes
size

Size of trial
mu

mu parameter for negative binomial
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the pdf value of with dProb that has the derivatives with respect to the parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikNbinomMu(46:54, 100, 40)

llikNbinomMu(46:54, 100, 40, TRUE)

Log likelihood for normal distribution

Description

Log likelihood for normal distribution

Usage

llikNorm(x, mean = 0, sd = 1, full = FALSE)

Arguments

x

Observation
mean

Mean for the likelihood
sd

Standard deviation for the likelihood
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the pdf value of with dMean and dSd that has the derivatives with respect to the parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikNorm(0)

llikNorm(seq(-2,2,length.out=10), full=TRUE)

log-likelihood for the Poisson distribution

Description

log-likelihood for the Poisson distribution

Usage

llikPois(x, lambda, full = FALSE)

Arguments

x

non negative integers
lambda

non-negative means
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the pdf value of with dLambda that has the derivatives with respect to the parameters at the observation time-point

Author(s)

Matthew L. Fidler

Log likelihood of T and it's derivatives (from stan)

Description

Log likelihood of T and it's derivatives (from stan)

Usage

llikT(x, df, mean = 0, sd = 1, full = FALSE)

Arguments

x

Observation
df

degrees of freedom (>0> 0, maybe non-integer). df = Inf is allowed.
mean

Mean for the likelihood
sd

Standard deviation for the likelihood
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dDf dMean and dSd that has the derivatives with respect to the parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

x <- seq(-3, 3, length.out = 21)

llikT(x, 7, 0, 1)

llikT(x, 15, 0, 1, full=TRUE)

log likelihood and derivatives for Unif distribution

Description

log likelihood and derivatives for Unif distribution

Usage

llikUnif(x, alpha, beta, full = FALSE)

Arguments

x

variable distributed by a uniform distribution
alpha

is the lower limit of the uniform distribution
beta

is the upper limit of the distribution
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dProb that has the derivatives with respect to the prob parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikUnif(1, -2, 2)

log likelihood and derivatives for Weibull distribution

Description

log likelihood and derivatives for Weibull distribution

Usage

llikWeibull(x, shape, scale, full = FALSE)

Arguments

x

variable distributed by a Weibull distribution
shape, scale

shape and scale parameters, the latter defaulting to 1.
full

Add the data frame showing x, mean, sd as well as the fx and derivatives

Value

data frame with fx for the log pdf value of with dProb that has the derivatives with respect to the prob parameters at the observation time-point

Author(s)

Matthew L. Fidler

Examples

llikWeibull(1, 1, 10)