Package: rxode2 Version: 5.1.3 Title: Facilities for Simulating from ODE-Based Models Authors@R: c( person("Matthew L.","Fidler", role = c("aut", "cre"), email = "matthew.fidler@gmail.com", comment=c(ORCID="0000-0001-8538-6691")), person("Wenping", "Wang", role = c("aut"), email = "wwang8198@gmail.com"), person("Alan", "Hindmarsh",role="ctb"), person("Arun", "Srinivasan", role="ctb", email="arunkumar.sriniv@gmail.com"), person("Awad H.", "Al-Mohy",role="ctb"), person("Bill", "Denney", email="wdenney@humanpredictions.com", role="ctb", comment=c(ORCID="0000-0002-5759-428X")), person("Cleve", "Moler", role="ctb"), person("Daniel", "Kaschek", email="daniel.kaschek@gmail.com", role="ctb"), person("David", "Cooley", role="ctb"), person("Drew", "Schmidt", role="ctb"), person("Ernst", "Hairer", role="ctb"), person("Gabriel", "Staples", role="ctb"), person("Gerhard", "Wanner", role="ctb"), person("Gilbert", "Stewart", role="ctb"), person("Goro", "Fuji", role="ctb", email="gfuji@cpan.org"), person("Hadley", "Wickham", role="ctb"), person("Hidde", "van de Beek", role="ctb", email="hiddevdbeek@icloud.com"), person("Igor", "Kushnir", email="igorkuo@gmail.com", role="ctb"), person("Imperial College of Science, Technology and Medicine", role="cph"), person("Jack", "Dongarra", role="ctb"), person("Jacob", "Williams", role="ctb"), person("Jim", "Bunch", role="ctb"), person("Karline", "Soetaert", role="ctb"), person("Kevin", "Ushey", role="ctb"), person("Linda", "Petzold", role="ctb"), person("Mark M.", "Baum", role="ctb"), person("Martin", "Maechler", role="ctb"), person("Matt", "Dowle", role="ctb", email="mattjdowle@gmail.com"), person("Matteo", "Fasiolo", email = "matteo.fasiolo@gmail.com", role = "ctb"), person("Melissa", "Hallow", role = "aut", email = "hallowkm@uga.edu"), person("Michel", "Lang", , "michellang@gmail.com", role = "ctb"), person("Morwenn","", role="ctb"), person("Nicholas J.", "Higham",role="ctb"), person("Omar", "Elashkar", email="omar.i.elashkar@gmail.com", role="ctb"), person("Peter N.", "Brown", role="ctb"), person("Rich", "FitzJohn", role="ctb", email="rich.fitzjohn@gmail.com"), person("Richard", "Upton", role = "ctb"), person("Roger B.", "Sidje", role="ctb"), person("Simon", "Frost", role="ctb"), person("Thomas", "Petzoldt", role="ctb"), person("Wes", "Hinsley", role="ctb"), person("Woodrow", "Setzer", role="ctb"), person("Yu", "Feng", role="ctb"), person("Zufar", "Mulyukov", role="ctb", email="zufar.mulyukov@novartis.com")) Maintainer: Matthew L. Fidler Depends: R (>= 4.1.0) Suggests: Matrix, DT, covr, crayon, curl, digest, dplyr (>= 0.8.0), ggrepel, gridExtra, htmltools, knitr, learnr, microbenchmark, nlme, remotes, rlang, rmarkdown, scales, shiny, stringi, symengine, testthat, tidyr, usethis, withr, xgxr, pillar, tibble, units (>= 0.6-0), rsconnect, devtools, patchwork, nlmixr2data, lifecycle, kableExtra, pmxTools, rootSolve, memuse Imports: PreciseSums (>= 0.7), Rcpp (>= 0.12.3), backports, cli (>= 2.0.0), checkmate, ggplot2 (>= 3.4.0), inline, lotri (>= 1.0.4), memoise, methods, rex, sys, tools, utils, dparser (>= 1.3.1-12), rxode2ll (>= 2.0.9), data.table (>= 1.12.4), qs2, vctrs, stats Description: Facilities for running simulations from ordinary differential equation ('ODE') models, such as pharmacometrics and other compartmental models. A compilation manager translates the ODE model into C, compiles it, and dynamically loads the object code into R for improved computational efficiency. An event table object facilitates the specification of complex dosing regimens (optional) and sampling schedules. NB: The use of this package requires both C and Fortran compilers, for details on their use with R please see Section 6.3, Appendix A, and Appendix D in the "R Administration and Installation" manual. Also the code is mostly released under GPL. The 'VODE' and 'LSODA' are in the public domain. The information is available in the inst/COPYRIGHTS. BugReports: https://github.com/nlmixr2/rxode2/issues/ NeedsCompilation: yes VignetteBuilder: knitr License: GPL (>= 3) URL: https://nlmixr2.github.io/rxode2/, https://github.com/nlmixr2/rxode2/ Biarch: true LinkingTo: sitmo, lotri (>= 1.0.0), PreciseSums (>= 0.7), Rcpp, RcppArmadillo (>= 0.9.300.2.0), BH, RcppParallel, RcppEigen (>= 0.3.3.9.2), sundialr (>= 0.1.7), dparser (>= 1.3.1-12), StanHeaders (>= 2.21.0.7) Encoding: UTF-8 LazyData: true Language: en-US Roxygen: list(markdown = TRUE) Config/testthat/edition: 3 Config/roxygen2/version: 8.0.0 Config/pak/sysreqs: cmake make Repository: https://nlmixr2.r-universe.dev Date/Publication: 2026-07-01 21:31:26 UTC RemoteUrl: https://github.com/nlmixr2/rxode2 RemoteRef: HEAD RemoteSha: eb2e5334218ad68a82818c403d448a65bc4fc190 Packaged: 2026-07-01 23:19:51 UTC; root Author: Matthew L. Fidler [aut, cre] (ORCID: ), Wenping Wang [aut], Alan Hindmarsh [ctb], Arun Srinivasan [ctb], Awad H. Al-Mohy [ctb], Bill Denney [ctb] (ORCID: ), Cleve Moler [ctb], Daniel Kaschek [ctb], David Cooley [ctb], Drew Schmidt [ctb], Ernst Hairer [ctb], Gabriel Staples [ctb], Gerhard Wanner [ctb], Gilbert Stewart [ctb], Goro Fuji [ctb], Hadley Wickham [ctb], Hidde van de Beek [ctb], Igor Kushnir [ctb], Imperial College of Science, Technology and Medicine [cph], Jack Dongarra [ctb], Jacob Williams [ctb], Jim Bunch [ctb], Karline Soetaert [ctb], Kevin Ushey [ctb], Linda Petzold [ctb], Mark M. Baum [ctb], Martin Maechler [ctb], Matt Dowle [ctb], Matteo Fasiolo [ctb], Melissa Hallow [aut], Michel Lang [ctb], Morwenn [ctb], Nicholas J. Higham [ctb], Omar Elashkar [ctb], Peter N. Brown [ctb], Rich FitzJohn [ctb], Richard Upton [ctb], Roger B. Sidje [ctb], Simon Frost [ctb], Thomas Petzoldt [ctb], Wes Hinsley [ctb], Woodrow Setzer [ctb], Yu Feng [ctb], Zufar Mulyukov [ctb]