Package: rxode2 Version: 5.1.8 Title: Facilities for Simulating from ODE-Based Models Authors@R: c( person("Matthew L.","Fidler", role = c("aut", "cre"), email = "matthew.fidler@gmail.com", comment=c(ORCID="0000-0001-8538-6691")), person("Wenping", "Wang", role = c("aut"), email = "wwang8198@gmail.com"), person("Aaron", "Collier", role="ctb", comment="SUNDIALS/CVODE"), person("Alan", "Hindmarsh",role="ctb"), person("Arun", "Srinivasan", role="ctb", email="arunkumar.sriniv@gmail.com"), person("Ashley", "Crawford", role="ctb", comment="SUNDIALS/CVODE"), person("Awad H.", "Al-Mohy",role="ctb"), person("Bill", "Denney", email="wdenney@humanpredictions.com", role="ctb", comment=c(ORCID="0000-0002-5759-428X")), person("Brian", "Ripley", role="ctb"), person("Cleve", "Moler", role="ctb"), person("Cody J.", "Balos", role="ctb", comment="SUNDIALS/CVODE"), person("Dan", "Shumaker", role="ctb", comment="SUNDIALS/CVODE"), person("Daniel", "Kaschek", email="daniel.kaschek@gmail.com", role="ctb"), person("Daniel R.", "Reynolds", role="ctb", comment="SUNDIALS/CVODE"), person("David", "Cooley", role="ctb"), person("David J.", "Gardner", role="ctb", comment="SUNDIALS/CVODE"), person("Drew", "Schmidt", role="ctb"), person("Ernst", "Hairer", role="ctb"), person("Gabriel", "Staples", role="ctb"), person("Gerhard", "Wanner", role="ctb"), person("Gilbert", "Stewart", role="ctb"), person("Goro", "Fuji", role="ctb", email="gfuji@cpan.org"), person("Hadley", "Wickham", role="ctb"), person("Hidde", "van de Beek", role="ctb", email="hiddevdbeek@icloud.com"), person("Igor", "Kushnir", email="igorkuo@gmail.com", role="ctb"), person("Imperial College of Science, Technology and Medicine", role="cph"), person("Jack", "Dongarra", role="ctb"), person("Jacob", "Williams", role="ctb"), person("Jim", "Bunch", role="ctb"), person("Karline", "Soetaert", role="ctb"), person("Kevin", "Ushey", role="ctb"), person("Lawrence Livermore National Security", role="cph", comment="SUNDIALS/CVODE"), person("Linda", "Petzold", role="ctb"), person("Mark M.", "Baum", role="ctb"), person("Martin", "Maechler", role="ctb"), person("Matt", "Dowle", role="ctb", email="mattjdowle@gmail.com"), person("Matteo", "Fasiolo", email = "matteo.fasiolo@gmail.com", role = "ctb"), person("Melissa", "Hallow", role = "aut", email = "hallowkm@uga.edu"), person("Michel", "Lang", , "michellang@gmail.com", role = "ctb"), person("Morwenn","", role="ctb"), person("Nicholas J.", "Higham",role="ctb"), person("Omar", "Elashkar", email="omar.i.elashkar@gmail.com", role="ctb"), person("Peter N.", "Brown", role="ctb"), person("Radu", "Serban", role="ctb", comment="SUNDIALS/CVODE"), person("Rich", "FitzJohn", role="ctb", email="rich.fitzjohn@gmail.com"), person("Richard", "Upton", role = "ctb"), person("Roger B.", "Sidje", role="ctb"), person("Scott D.", "Cohen", role="ctb", comment="SUNDIALS/CVODE"), person("Simon", "Frost", role="ctb"), person("Slaven", "Peles", role="ctb", comment="SUNDIALS/CVODE"), person("Southern Methodist University", role="cph", comment="SUNDIALS/CVODE"), person("Thomas", "Petzoldt", role="ctb"), person("University of Maryland Baltimore County", role="cph", comment="SUNDIALS/CVODE"), person("Wes", "Hinsley", role="ctb"), person("Woodrow", "Setzer", role="ctb"), person("Yu", "Feng", role="ctb"), person("Zufar", "Mulyukov", role="ctb", email="zufar.mulyukov@novartis.com")) Maintainer: Matthew L. Fidler Depends: R (>= 4.1.0) Suggests: Matrix, DT, callr, covr, crayon, curl, digest, dplyr (>= 0.8.0), ggrepel, gridExtra, htmltools, knitr, learnr, microbenchmark, nlme, remotes, rlang, rmarkdown, scales, shiny, stringi, symengine, testthat, tidyr, usethis, withr, xgxr (>= 1.1.6), pillar, ps, tibble, units (>= 0.6-0), rsconnect, devtools, patchwork, nlmixr2data, lifecycle, kableExtra, pmxTools, rootSolve, arrow, fst, duckdb, DBI Imports: PreciseSums (>= 0.7), Rcpp (>= 0.12.3), backports, cli (>= 2.0.0), checkmate, compiler, ggplot2 (>= 3.4.0), inline, lotri (>= 1.0.4), memoise, methods, mirai, rex, sys, tools, utils, dparser (>= 1.3.1-14), qs2, rxode2ll (>= 2.0.18), rxode2lincmt (>= 0.1.0), data.table (>= 1.12.4), vctrs, stats Description: Facilities for running simulations from ordinary differential equation ('ODE') models, such as pharmacometrics and other compartmental models. A compilation manager translates the ODE model into C, compiles it, and dynamically loads the object code into R for improved computational efficiency. An event table object facilitates the specification of complex dosing regimens (optional) and sampling schedules. NB: The use of this package requires both C and Fortran compilers, for details on their use with R please see Section 6.3, Appendix A, and Appendix D in the "R Administration and Installation" manual. Also the code is mostly released under GPL. The 'VODE' and 'LSODA' are in the public domain. The vendored 'SUNDIALS' 'CVODE' sources and headers are released under the BSD-3-Clause license. The information is available in the inst/COPYRIGHTS. BugReports: https://github.com/nlmixr2/rxode2/issues/ NeedsCompilation: yes VignetteBuilder: knitr License: GPL (>= 3) URL: https://nlmixr2.github.io/rxode2/, https://github.com/nlmixr2/rxode2/ Biarch: true LinkingTo: sitmo, rxode2lincmt (>= 0.1.0), lotri (>= 1.0.4), PreciseSums (>= 0.7), Rcpp, RcppArmadillo (>= 0.9.300.2.0), BH, dparser (>= 1.3.1-14) Encoding: UTF-8 LazyData: true Language: en-US Roxygen: list(markdown = TRUE) Config/testthat/edition: 3 Config/roxygen2/version: 8.1.0 Config/pak/sysreqs: cmake make Repository: https://nlmixr2.r-universe.dev Date/Publication: 2026-10-13 02:15:39 UTC RemoteUrl: https://github.com/nlmixr2/rxode2 RemoteRef: HEAD RemoteSha: 386e3dce3cb4d8cecfca19788b3319b555b30aaa Packaged: 2026-10-13 03:54:17 UTC; root Author: Matthew L. Fidler [aut, cre] (ORCID: ), Wenping Wang [aut], Aaron Collier [ctb] (SUNDIALS/CVODE), Alan Hindmarsh [ctb], Arun Srinivasan [ctb], Ashley Crawford [ctb] (SUNDIALS/CVODE), Awad H. Al-Mohy [ctb], Bill Denney [ctb] (ORCID: ), Brian Ripley [ctb], Cleve Moler [ctb], Cody J. Balos [ctb] (SUNDIALS/CVODE), Dan Shumaker [ctb] (SUNDIALS/CVODE), Daniel Kaschek [ctb], Daniel R. Reynolds [ctb] (SUNDIALS/CVODE), David Cooley [ctb], David J. Gardner [ctb] (SUNDIALS/CVODE), Drew Schmidt [ctb], Ernst Hairer [ctb], Gabriel Staples [ctb], Gerhard Wanner [ctb], Gilbert Stewart [ctb], Goro Fuji [ctb], Hadley Wickham [ctb], Hidde van de Beek [ctb], Igor Kushnir [ctb], Imperial College of Science, Technology and Medicine [cph], Jack Dongarra [ctb], Jacob Williams [ctb], Jim Bunch [ctb], Karline Soetaert [ctb], Kevin Ushey [ctb], Lawrence Livermore National Security [cph] (SUNDIALS/CVODE), Linda Petzold [ctb], Mark M. Baum [ctb], Martin Maechler [ctb], Matt Dowle [ctb], Matteo Fasiolo [ctb], Melissa Hallow [aut], Michel Lang [ctb], Morwenn [ctb], Nicholas J. Higham [ctb], Omar Elashkar [ctb], Peter N. Brown [ctb], Radu Serban [ctb] (SUNDIALS/CVODE), Rich FitzJohn [ctb], Richard Upton [ctb], Roger B. Sidje [ctb], Scott D. Cohen [ctb] (SUNDIALS/CVODE), Simon Frost [ctb], Slaven Peles [ctb] (SUNDIALS/CVODE), Southern Methodist University [cph] (SUNDIALS/CVODE), Thomas Petzoldt [ctb], University of Maryland Baltimore County [cph] (SUNDIALS/CVODE), Wes Hinsley [ctb], Woodrow Setzer [ctb], Yu Feng [ctb], Zufar Mulyukov [ctb]