{"name":"PK_1cmt","description":"One compartment PK model with linear clearance","parameters":"ka,cl,vc","DV":"Cc","linCmt":true,"algebraic":false,"dosing":"depot,central","filename":"PK_1cmt.R"}
{"name":"PK_1cmt_des","description":"One compartment PK model with linear clearance using differential equations","parameters":"ka,cl,vc","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"central,depot","filename":"PK_1cmt_des.R"}
{"name":"PK_2cmt","description":"Two compartment PK model with linear clearance","parameters":"ka,cl,vc,vp,q","DV":"Cc","linCmt":true,"algebraic":false,"dosing":"depot,central","filename":"PK_2cmt.R"}
{"name":"PK_2cmt_des","description":"Two compartment PK model with linear clearance using differential equations","parameters":"ka,cl,vc,vp,q","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"PK_2cmt_des.R"}
{"name":"PK_2cmt_no_depot","description":"Two compartment PK model with linear clearance using differential equations","parameters":"cl,vc,vp,q","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"central","filename":"PK_2cmt_no_depot.R"}
{"name":"PK_2cmt_tdcl_des","description":"Two compartment PK model with time-dependent clearance using differential equations (structured like nivolumab PK model)","parameters":"clts,cltmax,clgamma,clt50,vc,vp,q","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"central","filename":"PK_2cmt_tdcl_des.R"}
{"name":"PK_3cmt","description":"Three compartment PK model with linear clearance","parameters":"ka,cl,vc,vp,vp2,q,q2","DV":"Cc","linCmt":true,"algebraic":false,"dosing":"depot,central","filename":"PK_3cmt.R"}
{"name":"PK_3cmt_des","description":"Three compartment PK model with linear clearance using differential equations","parameters":"ka,cl,vc,vp,vp2,q,q2","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"PK_3cmt_des.R"}
{"name":"phenylalanine_charbonneau_2021","description":"Phenylalanine model for absorption and metabolism in healthy subjects and patients with PKU","parameters":"phe(0),gut(0),d/dt(gut),d/dt(phe),v_pah,v_pah,v_pah,v_pah,v_trans,v_trans,v_renal,v_renal","DV":"","linCmt":false,"algebraic":false,"filename":"endogenous/phenylalanine_charbonneau_2021.R"}
{"name":"indirect_0cpt_transitEx","description":"Two compartment PK model with Michealis-Menten clearance using differential equations","parameters":"ka,ktr1,ktr2,ktr3,ktr4,ktr5,ktr6,ktr7,ktr8,ktr9,ktr10,vm,km,vc,vp,q","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_0cpt_transitEx.R"}
{"name":"indirect_1cpt_inhi_kin","description":"One compartment indirect response model with inhibition of kin.","parameters":"ka,vc,kel,IC50,imax,kin,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_inhi_kin.R"}
{"name":"indirect_1cpt_inhi_kin_CLV","description":"One compartment indirect response model with inhibition of kin.","parameters":"ka,vc,cl,IC50,imax,kin,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_inhi_kin_CLV.R"}
{"name":"indirect_1cpt_inhi_kin_r0rmaxcrmax","description":"One compartment indirect response model with inhibition of kin.","parameters":"ka,vc,cl,r0,rmax,s1,imax,crmax,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_inhi_kin_r0rmaxcrmax.R"}
{"name":"indirect_1cpt_inhi_kout","description":"One compartment indirect response model with inhibition of kout.","parameters":"ka,vc,kel,IC50,kin,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_inhi_kout.R"}
{"name":"indirect_1cpt_inhi_kout_CLV","description":"One compartment indirect response model with inhibition of kout.","parameters":"ka,vc,cl,IC50,kin,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_inhi_kout_CLV.R"}
{"name":"indirect_1cpt_inhi_kout_r0rmaxcrmax","description":"One compartment indirect response model with inhibition of kout.","parameters":"ka,vc,cl,r0,rmax,s1,imax,crmax,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_inhi_kout_r0rmaxcrmax.R"}
{"name":"indirect_1cpt_stim_kin","description":"One compartment indirect response model with stimulation of kin.Parameterized using rate cosntants","parameters":"ka,vc,kel,EC50,Emax,kin,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_stim_kin.R"}
{"name":"indirect_1cpt_stim_kin_CLV","description":"One compartment indirect response model with stimulation of kin.","parameters":"ka,vc,cl,EC50,Emax,kin,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_stim_kin_CLV.R"}
{"name":"indirect_1cpt_stim_kin_r0rmaxcrmax","description":"One compartment indirect response model with stimulation of kin.","parameters":"ka,vc,cl,r0,rmax,s1,emax,crmax,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_stim_kin_r0rmaxcrmax.R"}
{"name":"indirect_1cpt_stim_kout","description":"One compartment indirect response model with stimulation of kout.Parameterized using rate cosntants","parameters":"ka,kel,EC50,Emax,kin,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_stim_kout.R"}
{"name":"indirect_1cpt_stim_kout_CLV","description":"One compartment indirect response model with stimulation of kout.","parameters":"ka,vc,cl,EC50,Emax,kin,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_stim_kout_CLV.R"}
{"name":"indirect_1cpt_stim_kout_r0rmaxcrmax","description":"One compartment indirect response model with stimulation of kout.","parameters":"ka,vc,cl,r0,rmax,s1,emax,crmax,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_1cpt_stim_kout_r0rmaxcrmax.R"}
{"name":"indirect_circ_1cpt_inhi_kin_kin_t","description":"One compartment indirect response model with inhibition of kin and circadian kin_t.","parameters":"ka,vc,kel,rm,ra,tz,IC50,imax,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_circ_1cpt_inhi_kin_kin_t.R"}
{"name":"indirect_circ_1cpt_inhi_kin_kout_t","description":"One compartment indirect response model with inhibition of kin and circadian kin_t.","parameters":"ka,kel,rm,ra,tz,IC50,imax,kin,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_circ_1cpt_inhi_kin_kout_t.R"}
{"name":"indirect_circ_1cpt_inhi_kout_kin_t","description":"One compartment indirect response model with inhibition of kout and circadian kin_t.","parameters":"ka,kel,rm,ra,tz,IC50,imax,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_circ_1cpt_inhi_kout_kin_t.R"}
{"name":"indirect_circ_1cpt_inhi_kout_kout_t","description":"One compartment indirect response model with inhibition of kout and circadian kin_t.","parameters":"ka,kel,rm,ra,tz,IC50,imax,kin,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_circ_1cpt_inhi_kout_kout_t.R"}
{"name":"indirect_circ_1cpt_stim_kin_kin_t","description":"One compartment indirect response model with stimulation of kin and circadian kin_t.Parameterized using rate cosntants","parameters":"ka,kel,rm,ra,tz,EC50,Emax,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_circ_1cpt_stim_kin_kin_t.R"}
{"name":"indirect_circ_1cpt_stim_kin_kout_t","description":"One compartment indirect response model with stimulation of kin and circadian kout_t.Parameterized using rate constants","parameters":"ka,kel,rm,ra,tz,EC50,Emax,kin,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_circ_1cpt_stim_kin_kout_t.R"}
{"name":"indirect_circ_1cpt_stim_kout_kin_t","description":"One compartment indirect response model with stimulation of kout and circadian kin_t.Parameterized using rate cosntants","parameters":"ka,kel,rm,ra,tz,EC50,Emax,kout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_circ_1cpt_stim_kout_kin_t.R"}
{"name":"indirect_circ_1cpt_stim_kout_kout_t","description":"One compartment indirect response model with stimulation of kout and circadian kout_t.Parameterized using rate cosntants","parameters":"ka,kel,rm,ra,tz,EC50,Emax,kin,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_circ_1cpt_stim_kout_kout_t.R"}
{"name":"indirect_prec_1cpt_inhi_CLV","description":"One compartment precursor-dependent indirect response model with inhibition of drug response. Parameterized with clearance and volume. (effect).","parameters":"ka,vc,cl,imax,IC50,kin,kout,kpin,kpout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_prec_1cpt_inhi_CLV.R"}
{"name":"indirect_prec_1cpt_inhi_r0rmaxcrmax","description":"One compartment precursor-dependent indirect response model with inhibition of drug response (effect).","parameters":"ka,vc,cl,r0,rmax,kout,kpin,kpout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_prec_1cpt_inhi_r0rmaxcrmax.R"}
{"name":"indirect_prec_1cpt_stim_CLV","description":"One compartment precursor-dependent indirect response model with inhibition of drug response (effect). Parameterized with clearance and volume","parameters":"ka,vc,cl,emax,EC50,kin,kout,kpin,kpout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_prec_1cpt_stim_CLV.R"}
{"name":"indirect_prec_1cpt_stim_r0rmaxcrmax","description":"One compartment precursor-dependent indirect response model with inhibition of drug response (effect). Parameterized with clearance and volume","parameters":"ka,vc,cl,r0,rmax,kout,kpin,kpout,fdepot","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"pharmacodynamics/indirect_prec_1cpt_stim_r0rmaxcrmax.R"}
{"name":"PK_2cmt_mAb_Davda_2014","description":"Two compartment PK model with linear clearance for average monoclonal antibodies (Davda 2014)","parameters":"fdepot,ka,cl,v,vp,q,cl,v","DV":"Cc","linCmt":true,"algebraic":false,"dosing":"depot,central","filename":"pharmacokinetics/PK_2cmt_mAb_Davda_2014.R"}
{"name":"PK_double_sim_01","description":"PK double absorption model with simultaneous zero order and first order absorptions","parameters":"k01,ka2,cl,vc,fdepot1,alag","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"central","filename":"pharmacokinetics/PK_double_sim_01.R"}
{"name":"PK_double_sim_10","description":"PK double absorption model with simultaneous first order and zero order absorptions","parameters":"ka1,k02,cl,vc,fdepot1,alag","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"central","filename":"pharmacokinetics/PK_double_sim_10.R"}
{"name":"PK_double_sim_11","description":"PK double absorption model with simultaneous first order absorptions","parameters":"ka1,ka2,cl,vc,fdepot1,alag","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"central","filename":"pharmacokinetics/PK_double_sim_11.R"}
{"name":"CarlssonPetri_2021_liraglutide","description":"Liraglutide PK model in adolescents (Carlsson Petri 2021)","parameters":"ka,cl,cl_wt,cl_sex,cl_age,cl_age,vc,vc_wt","DV":"Cc","linCmt":true,"algebraic":false,"dosing":"depot,central","filename":"specificDrugs/CarlssonPetri_2021_liraglutide.R"}
{"name":"Cirincione_2017_exenatide","description":"Exenatide immediate-release PK model (Cirincione 2017)","parameters":"cl,cl,q,km,vmax,vp,vc,vc,kamax,kmka,mtime(tau),f(depot),fr","DV":"otherStudy,study1,study5","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"specificDrugs/Cirincione_2017_exenatide.R"}
{"name":"Kovalenko_2020_dupilumab","description":"Dupilumab PK model (Kovalenko 2020)","parameters":"vc,ke,kcp,kpc,ka,MTT,Vm,d/dt(central),f(depot),vc","DV":"Cc","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"specificDrugs/Kovalenko_2020_dupilumab.R"}
{"name":"Soehoel_2022_tralokinumab","description":"Tralokinumab PK model (Soehoel 2022)","parameters":"ka,vc,cl,vp,q,fdepot,vc,cl,cl,vc,fdepot,ka","DV":"Cc","linCmt":true,"algebraic":false,"dosing":"depot,central","filename":"specificDrugs/Soehoel_2022_tralokinumab.R"}
{"name":"Zhu_2017_lebrikizumab","description":"Lebrikizumab PK model (Zhu 2017)","parameters":"cl,vc,vp,q,ka,fdepot,cl,vc,vp,q,cl,cl,cl,cl,cl,ka,ka,fdepot,fdepot,cl","DV":"Cc","linCmt":true,"algebraic":false,"dosing":"depot,central","filename":"specificDrugs/Zhu_2017_lebrikizumab.R"}
{"name":"oncology_sdm_lobo_2002","description":"Signal transduction model for delayed concentration effects on cancer cell growth","parameters":"kng,tau,ec50,drugEffectTumorVol","DV":"tumorVol","linCmt":false,"algebraic":false,"depends":"Cc","filename":"therapeuticArea/oncology/oncology_sdm_lobo_2002.R"}
{"name":"oncology_xenograft_simeoni_2004","description":"Oncology tumor growth model in xenograft models","parameters":"damageTransit,drugSlope,tumorExpGrowth,tumorLinGrowth","DV":"tumorVol","linCmt":false,"algebraic":false,"depends":"Cc","filename":"therapeuticArea/oncology/oncology_xenograft_simeoni_2004.R"}
{"name":"tgi_no_sat_Koch","description":"One compartment TGI model with with exponential tumor growth, without saturation.","parameters":"ts0,ka,cl,vc,kgl,kge","DV":"Cc,tumorSize","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"therapeuticArea/oncology/tgi_no_sat_Koch.R"}
{"name":"tgi_no_sat_expo","description":"One compartment TGI model with with exponential tumor growth, without saturation.","parameters":"ts0,ka,cl,vc,kge","DV":"Cc,tumorSize","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"therapeuticArea/oncology/tgi_no_sat_expo.R"}
{"name":"tgi_no_sat_linear","description":"One compartment TGI model with with linear tumor growth, without saturation.","parameters":"ts0,ka,cl,vc,kgl","DV":"Cc,tumorSize","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"therapeuticArea/oncology/tgi_no_sat_linear.R"}
{"name":"tgi_no_sat_powerLaw","description":"One compartment TGI model with with exponential tumor growth, without saturation.","parameters":"ts0,ka,cl,vc,gamma,kgl,kge","DV":"Cc,tumorSize","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"therapeuticArea/oncology/tgi_no_sat_powerLaw.R"}
{"name":"tgi_sat_VonBertalanffy","description":"One compartment TGI model where tumor growth is limited by a loss term, with saturation.","parameters":"ts0,tsmax,ka,cl,vc,kg,kd","DV":"Cc,tumorSize","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"therapeuticArea/oncology/tgi_sat_VonBertalanffy.R"}
{"name":"tgi_sat_genVonBertalanffy","description":"One compartment TGI model where tumor growth is limited by a loss term, with saturation.","parameters":"ts0,tsmax,ka,cl,vc,kg,kd,gamma","DV":"Cc,tumorSize","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"therapeuticArea/oncology/tgi_sat_genVonBertalanffy.R"}
{"name":"tgi_sat_logistic","description":"One compartment TGI model with with exponential tumor growth that decelerates linearly, with saturation.","parameters":"ts0,tsmax,ka,cl,vc,kgl","DV":"Cc,tumorSize","linCmt":false,"algebraic":false,"dosing":"depot,central","filename":"therapeuticArea/oncology/tgi_sat_logistic.R"}