Package: nlmixr2extra
Title: Nonlinear Mixed Effects Models in Population PK/PD, Extra
        Support Functions
Version: 5.1.0
Authors@R: c(
    person("Matthew", "Fidler", email="matthew.fidler@gmail.com", role = c("aut", "cre"),
           comment = c(ORCID = "0000-0001-8538-6691")),
    person("Vipul", "Mann",email="vm2583@columbia.edu", role = "aut"),
    person("Vishal", "Sarsani", email="vsarsani@umass.edu", comment=c(ORCID = "0000-0002-9272-3438"), role="aut"),
    person("Christian", "Bartels", email="christian.bartels@novartis.com", role="ctb"),
    person("Bill", "Denney", email="wdenney@humanpredictions.com", role="aut", comment=c(ORCID="0000-0002-5759-428X")),
    person("Omar", "Elashkar", email="omar.i.elashkar@gmail.com", role="ctb", comment=c(ORCID="0000-0002-5505-778X"))
  )
Maintainer: Matthew Fidler <matthew.fidler@gmail.com>
Description: Fit and compare nonlinear mixed-effects models in
        differential equations with flexible dosing information
        commonly seen in pharmacokinetics and pharmacodynamics
        (Almquist, Leander, and Jirstrand 2015
        <doi:10.1007/s10928-015-9409-1>). Differential equation solving
        is by compiled C code provided in the 'rxode2' package (Wang,
        Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package
        is for support functions like preconditioned fits
        <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise
        covariate selection.
Depends: R (>= 4.1)
License: GPL (>= 3)
URL: https://nlmixr2.github.io/nlmixr2extra/,
        https://github.com/nlmixr2/nlmixr2extra/
BugReports: https://github.com/nlmixr2/nlmixr2extra/issues/
Imports: checkmate, cli (>= 3.4.0), crayon, data.table, digest, dplyr,
        ggplot2, ggtext, knitr, lotri, magrittr, methods, nlme,
        nlmixr2est (>= 6.0.0), Rcpp, rxode2 (>= 5.1.0), stats,
        symengine, utils
Suggests: brms, nlmixr2data, rmarkdown, tidyr, nlmixr2lib, testthat (>=
        3.0.0), withr
LinkingTo: Rcpp, RcppArmadillo
Biarch: true
Config/testthat/edition: 3
Encoding: UTF-8
NeedsCompilation: yes
Roxygen: list(markdown = TRUE)
LazyData: true
Config/roxygen2/version: 8.0.0
Config/pak/sysreqs: libgmp3-dev make libicu-dev libjpeg-dev libpng-dev
        libxml2-dev libssl-dev
Repository: https://nlmixr2.r-universe.dev
Date/Publication: 2026-06-10 02:42:19 UTC
RemoteUrl: https://github.com/nlmixr2/nlmixr2extra
RemoteRef: HEAD
RemoteSha: 8f290089514ee4811c1190989f3b02b83e47b4c5
Packaged: 2026-07-02 03:01:29 UTC; root
Author: Matthew Fidler [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-8538-6691>),
  Vipul Mann [aut],
  Vishal Sarsani [aut] (ORCID: <https://orcid.org/0000-0002-9272-3438>),
  Christian Bartels [ctb],
  Bill Denney [aut] (ORCID: <https://orcid.org/0000-0002-5759-428X>),
  Omar Elashkar [ctb] (ORCID: <https://orcid.org/0000-0002-5505-778X>)