Type: Package
Package: nlmixr2est
Title: Nonlinear Mixed Effects Models in Population PK/PD, Estimation
        Routines
Version: 7.2.1
Authors@R: c(
    person("Matthew", "Fidler", , "matthew.fidler@gmail.com", role = c("aut", "cre"), comment = c(ORCID = "0000-0001-8538-6691")),
    person("Wenping", "Wang", , "wwang8198@gmail.com", role = "aut"),
    person("Audrey", "Lavenu", role = "ctb"),
    person("Ben", "Goodrich", role = "ctb"),
    person("David", "Ardia", role = "cph"),
    person("Dirk", "Eddelbuettel", , "edd@debian.org", role = "cph"),
    person("Elizabeth", "Eskow", role = "ctb"),
    person("Emmanuelle", "Comets", , "emmanuelle.comets@inserm.fr", role = "ctb"),
    person("Hadley", "Wickham", role = "ctb"),
    person("Hajar", "Besbassi", , "", role="ctb"),
    person("Hidde", "van de Beek", , "hiddevdbeek@icloud.com", role = "ctb"),
    person("Johannes", "Pfeifer", role = "ctb"),
    person("Justin", "Wilkins", , "justin.wilkins@occams.com", role = "aut", comment = c(ORCID = "0000-0002-7099-9396")),
    person("Katharine", "Mullen", role = "cph"),
    person("Mahmoud", "Abdelwahab", , "mah.tareq87@gmail.com", role = "ctb"),
    person("Marc", "Lavielle", role = "ctb"),
    person("Mason", "McComb", , "mason.c.mccomb@gmail.com", role = "ctb", comment = c(ORCID = "0000-0001-9871-8616")),
    person("Mirjam", "Trame", , "mirjam.trame@gmail.com", role = "ctb"),
    person("Richard", "Hooijmaijers", , "richardhooijmaijers@gmail.com", role = "aut"),
    person("Rik", "Schoemaker", , "rik.schoemaker@occams.com", role = "aut",  comment = c(ORCID = "0000-0002-7538-3005")),
    person("Robert B.", "Schnabel", role = "ctb"),
    person("Robert", "Leary", role = "ctb"),
    person("Teun", "Post", , "t.post@lapp.nl", role = "ctb"),
    person("Vipul", "Mann", , "vm2583@columbia.edu", role = "aut"),
    person("Yuan", "Xiong", , "yuan.xiong@gmail.com", role = "aut")
  )
Maintainer: Matthew Fidler <matthew.fidler@gmail.com>
Description: Fit and compare nonlinear mixed-effects models in
        differential equations with flexible dosing information
        commonly seen in pharmacokinetics and pharmacodynamics
        (Almquist, Leander, and Jirstrand 2015
        <doi:10.1007/s10928-015-9409-1>). Differential equation solving
        is by compiled C code provided in the 'rxode2' package (Wang,
        Hallow, and James 2015 <doi:10.1002/psp4.12052>).
License: GPL (>=3)
URL: https://github.com/nlmixr2/nlmixr2est,
        https://nlmixr2.github.io/nlmixr2est/
Depends: nlmixr2data, R (>= 4.1.0)
Imports: backports, checkmate, cli, graphics, knitr, L0Learn, lbfgsb3c
        (>= 2024-3.6), lotri, methods, minqa, n1qn1 (>= 6.0.1-12),
        nlme, Rcpp, RcppTrust (>= 0.1.0), rex, rxode2 (>= 5.1.8),
        stats, symengine, utils
Suggests: broom.mixed, callr, crayon, data.table, devtools, digest,
        dplyr (>= 1.1.0), generics, nloptr, sys, testthat, tibble,
        withr, xgxr, sfsmisc, minpack.lm, Matrix, remotes, fastGHQuad,
        rmarkdown, rlang, numDeriv, rstan, loo
LinkingTo: BH, n1qn1 (>= 6.0.1-12), lbfgsb3c (>= 2024-3.6), lotri (>=
        0.5.0), Rcpp, RcppArmadillo (>= 0.11.2.3.1), RcppEigen,
        RcppTrust (>= 0.1.0), rxode2 (>= 5.1.8)
Biarch: true
Config/testthat/edition: 3
Encoding: UTF-8
Language: en-US
NeedsCompilation: yes
LazyData: true
VignetteBuilder: knitr
Config/roxygen2/version: 8.1.0
Config/pak/sysreqs: cmake libgmp3-dev make libicu-dev
Repository: https://nlmixr2.r-universe.dev
Date/Publication: 2026-10-15 03:28:48 UTC
RemoteUrl: https://github.com/nlmixr2/nlmixr2est
RemoteRef: HEAD
RemoteSha: 01137506545cd3381ea6fd62f09a3bc153495d88
Packaged: 2026-10-20 20:15:21 UTC; root
Author: Matthew Fidler [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-8538-6691>),
  Wenping Wang [aut],
  Audrey Lavenu [ctb],
  Ben Goodrich [ctb],
  David Ardia [cph],
  Dirk Eddelbuettel [cph],
  Elizabeth Eskow [ctb],
  Emmanuelle Comets [ctb],
  Hadley Wickham [ctb],
  Hajar Besbassi [ctb],
  Hidde van de Beek [ctb],
  Johannes Pfeifer [ctb],
  Justin Wilkins [aut] (ORCID: <https://orcid.org/0000-0002-7099-9396>),
  Katharine Mullen [cph],
  Mahmoud Abdelwahab [ctb],
  Marc Lavielle [ctb],
  Mason McComb [ctb] (ORCID: <https://orcid.org/0000-0001-9871-8616>),
  Mirjam Trame [ctb],
  Richard Hooijmaijers [aut],
  Rik Schoemaker [aut] (ORCID: <https://orcid.org/0000-0002-7538-3005>),
  Robert B. Schnabel [ctb],
  Robert Leary [ctb],
  Teun Post [ctb],
  Vipul Mann [aut],
  Yuan Xiong [aut]