Package: nlmixr2
Title: Nonlinear Mixed Effects Models in Population PK/PD
Version: 6.0.0
Authors@R: c(person("Matthew","Fidler", role = c("aut", "cre"), email = "matthew.fidler@gmail.com", comment=c(ORCID="0000-0001-8538-6691")),
   person("Anne", "Keunecke", role="ctb"),
   person("Rik", "Schoemaker", role = "ctb", email = "rik.schoemaker@occams.com", comment=c(ORCID="0000-0002-7538-3005")),
   person("Justin", "Wilkins", role = "ctb", email = "justin.wilkins@occams.com", comment=c(ORCID="0000-0002-7099-9396")),
   person("Wenping", "Wang", role = "ctb", email = "wwang8198@gmail.com"),
   person("Mirjam","Trame", role = "ctb", email="mirjam.trame@gmail.com"),
   person("John", "Harrold", role="ctb", email="john.m.harrold@gmail.com"),
   person("Bill", "Denney", email="wdenney@humanpredictions.com", role="ctb", comment=c(ORCID="0000-0002-5759-428X")),
   person("Theodoros", "Papathanasiou",  role="ctb"),
   person("Richard", "Hooijmaijers", email = "richardhooijmaijers@gmail.com", role = "ctb"),
   person("Michael Wayne", "Kearney", email = "kearneymw@missouri.edu", role = "ctb",comment = c(ORCID = "0000-0002-0730-4694")))
Description: Fit and compare nonlinear mixed-effects models in
        differential equations with flexible dosing information
        commonly seen in pharmacokinetics and pharmacodynamics
        (Almquist, Leander, and Jirstrand 2015
        <doi:10.1007/s10928-015-9409-1>). Differential equation solving
        is by compiled C code provided in the 'rxode2' package (Wang,
        Hallow, and James 2015 <doi:10.1002/psp4.12052>).
License: GPL (>= 3)
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.3.2
Imports: clisymbols, cli (>= 1.0.0), crayon (>= 1.3.4), dplyr (>=
        0.7.4), purrr (>= 0.2.4), rstudioapi (>= 0.7), nlmixr2est (>=
        5.0.0), nlmixr2extra (>= 5.0.0), rxode2 (>= 5.0.0), lotri (>=
        0.4.3), nlmixr2plot (>= 5.0.0), tibble, magrittr
Suggests: rmarkdown, knitr, devtools, ggplot2, testthat, n1qn1, withr
BugReports: https://github.com/nlmixr2/nlmixr2/issues/
URL: https://nlmixr2.org/, https://github.com/nlmixr2/nlmixr2/
Config/pak/sysreqs: cmake libfontconfig1-dev libfreetype6-dev
        libgmp3-dev make libicu-dev libjpeg-dev libpng-dev libuv1-dev
        libxml2-dev libssl-dev libx11-dev zlib1g-dev
Repository: https://nlmixr2.r-universe.dev
Date/Publication: 2026-05-22 00:44:43 UTC
RemoteUrl: https://github.com/nlmixr2/nlmixr2
RemoteRef: HEAD
RemoteSha: f8bc49795d54356e63ec2ca23d5e17db26c0ee36
NeedsCompilation: no
Packaged: 2026-07-02 03:03:09 UTC; root
Author: Matthew Fidler [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-8538-6691>),
  Anne Keunecke [ctb],
  Rik Schoemaker [ctb] (ORCID: <https://orcid.org/0000-0002-7538-3005>),
  Justin Wilkins [ctb] (ORCID: <https://orcid.org/0000-0002-7099-9396>),
  Wenping Wang [ctb],
  Mirjam Trame [ctb],
  John Harrold [ctb],
  Bill Denney [ctb] (ORCID: <https://orcid.org/0000-0002-5759-428X>),
  Theodoros Papathanasiou [ctb],
  Richard Hooijmaijers [ctb],
  Michael Wayne Kearney [ctb] (ORCID:
    <https://orcid.org/0000-0002-0730-4694>)
Maintainer: Matthew Fidler <matthew.fidler@gmail.com>