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  "Version": "0.3.2.9000",
  "Title": "A Model Library for 'nlmixr2'",
  "Description": "A model library for 'nlmixr2'.  The models include (and\nplan to include) pharmacokinetic, pharmacodynamic, and disease\nmodels used in pharmacometrics.  Where applicable, references\nfor each model are included in the meta-data for each\nindividual model.  The package also includes model composition\nand modification functions to make model updates easier.",
  "Authors@R": "c(\nperson(\"Richard\",\"Hooijmaijers\", email=\"richardhooijmaijers@gmail.com\",role=\"aut\"),\nperson(\"Matthew\",\"Fidler\", email=\"matthew.fidler@gmail.com\",role=c(\"aut\"), comment=c(ORCID=\"0000-0001-8538-6691\")),\nperson(\"Bill\", \"Denney\", email=\"wdenney@humanpredictions.com\", role=c(\"aut\", \"cre\"), comment=c(ORCID=\"0000-0002-5759-428X\")),\nperson(\"Kiranmayi\", \"Vedantham\", email=\"kiranmayi.vedantham@gmail.com\", role=c(\"aut\"),comment=c(ORCID=\"0009-0003-0828-6445\"))\n)",
  "License": "GPL (>= 2)",
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  "VignetteBuilder": "knitr",
  "URL": "https://github.com/nlmixr2/nlmixr2lib,\nhttps://nlmixr2.github.io/nlmixr2lib/",
  "Encoding": "UTF-8",
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  "Repository": "https://nlmixr2.r-universe.dev",
  "Date/Publication": "2026-06-07 15:55:38 UTC",
  "RemoteUrl": "https://github.com/nlmixr2/nlmixr2lib",
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  "Packaged": {
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  "Author": "Richard Hooijmaijers [aut],\nMatthew Fidler [aut] (ORCID: <https://orcid.org/0000-0001-8538-6691>),\nBill Denney [aut, cre] (ORCID: <https://orcid.org/0000-0002-5759-428X>),\nKiranmayi Vedantham [aut] (ORCID:\n<https://orcid.org/0009-0003-0828-6445>)",
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    "addBaseline1exp",
    "addBaselineConst",
    "addBaselineExp",
    "addBaselineLin",
    "addBioavailability",
    "addCmtProp",
    "addDepot",
    "addDirectLin",
    "addDirToModelDb",
    "addDur",
    "addEffectCmtLin",
    "addEta",
    "addFileToModelDb",
    "addIndirect",
    "addIndirectLin",
    "addIni",
    "addLag",
    "addLogEstimates",
    "addRate",
    "addResErr",
    "addTransit",
    "addWeibullAbs",
    "assertCompartmentExists",
    "assertCompartmentName",
    "assertParameterValue",
    "assertRxUi",
    "assertRxUiEstimatedResiduals",
    "assertRxUiMixedOnly",
    "assertRxUiMuRefOnly",
    "assertRxUiNormal",
    "assertRxUiPopulationOnly",
    "assertRxUiPrediction",
    "assertRxUiRandomOnIdOnly",
    "assertRxUiSingleEndpoint",
    "assertRxUiTransformNormal",
    "assertVariableName",
    "blankCombine",
    "bsvToCv",
    "camelCombine",
    "checkModelConventions",
    "combinePaste2",
    "convertEmax",
    "convertEmaxHill",
    "convertKinR0",
    "convertLogLin",
    "convertMM",
    "convertQuad",
    "createMarkovModel",
    "createMarkovModelDataset",
    "createMarkovTransitionMatrix",
    "cvToBsv",
    "defaultCombine",
    "dotCombine",
    "expit",
    "fakeCc",
    "logit",
    "Mann2022Equilibrate",
    "modellib",
    "ncaComparisonTable",
    "ncaParamLabel",
    "pkTrans",
    "readModelDb",
    "register_lagState",
    "removeDepot",
    "removeLinesAndInis",
    "removeTransit",
    "searchReplace",
    "searchReplaceHelper",
    "setCombineType",
    "simMarkov",
    "snakeCombine",
    "updateOncologyXenograftSimeoni2004"
  ],
  "_datasets": [
    {
      "name": "modeldb",
      "title": "Model library for nlmixr2",
      "object": "modeldb",
      "class": [
        "data.frame"
      ],
      "fields": [
        "name",
        "description",
        "parameters",
        "DV",
        "linCmt",
        "algebraic",
        "dosing",
        "depends",
        "vignette",
        "label",
        "category",
        "filename"
      ],
      "rows": 839,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "addBaseline1exp",
      "title": "Add baseline that decays exponential with time",
      "concept": [
        "PD"
      ],
      "topics": [
        "addBaseline1exp"
      ]
    },
    {
      "page": "addBaselineConst",
      "title": "Add an estimated baseline constant",
      "concept": [
        "PD"
      ],
      "topics": [
        "addBaselineConst"
      ]
    },
    {
      "page": "addBaselineExp",
      "title": "Add baseline that decays exponential with time",
      "concept": [
        "PD"
      ],
      "topics": [
        "addBaselineExp"
      ]
    },
    {
      "page": "addBaselineLin",
      "title": "Add an estimated baseline linear constant",
      "concept": [
        "PD"
      ],
      "topics": [
        "addBaselineLin"
      ]
    },
    {
      "page": "addCmtProp",
      "title": "Add a property to a compartment",
      "topics": [
        "addBioavailability",
        "addCmtProp",
        "addDur",
        "addIni",
        "addLag",
        "addRate"
      ]
    },
    {
      "page": "addDepot",
      "title": "To convert from infusion/intravenous administration to first-order oral absorption",
      "topics": [
        "addDepot"
      ]
    },
    {
      "page": "addDirectLin",
      "title": "Add direct linear effect with baseline=0",
      "concept": [
        "PD"
      ],
      "topics": [
        "addDirectLin"
      ]
    },
    {
      "page": "addDirToModelDb",
      "title": "Add a directory to the modeldb",
      "topics": [
        "addDirToModelDb",
        "addFileToModelDb"
      ]
    },
    {
      "page": "addEffectCmtLin",
      "title": "Add effect compartment",
      "topics": [
        "addEffectCmtLin"
      ]
    },
    {
      "page": "addEta",
      "title": "Add random effects to a model",
      "topics": [
        "addEta"
      ]
    },
    {
      "page": "addIndirect",
      "title": "Add an indirect response model to a PK model",
      "concept": [
        "Indirect response"
      ],
      "topics": [
        "addIndirect"
      ]
    },
    {
      "page": "addIndirectLin",
      "title": "Add linear indirect response model",
      "concept": [
        "Indirect response"
      ],
      "topics": [
        "addIndirectLin"
      ]
    },
    {
      "page": "addLogEstimates",
      "title": "Add log estimates to a model",
      "topics": [
        "addLogEstimates"
      ]
    },
    {
      "page": "addResErr",
      "title": "Add residual error to a model",
      "topics": [
        "addResErr"
      ]
    },
    {
      "page": "addTransit",
      "title": "To add transit compartments to the model",
      "concept": [
        "absorption"
      ],
      "topics": [
        "addTransit"
      ]
    },
    {
      "page": "addWeibullAbs",
      "title": "Converts first order absorption model to Weibull absorption model",
      "concept": [
        "absorption"
      ],
      "topics": [
        "addWeibullAbs"
      ]
    },
    {
      "page": "checkModelConventions",
      "title": "Check a model against nlmixr2lib conventions",
      "topics": [
        "checkModelConventions"
      ]
    },
    {
      "page": "combinePaste2",
      "title": "Combine two strings using a naming convention",
      "topics": [
        "combinePaste2"
      ]
    },
    {
      "page": "convertEmax",
      "title": "Convert linear effect to Emax effect",
      "concept": [
        "PD"
      ],
      "topics": [
        "convertEmax"
      ]
    },
    {
      "page": "convertEmaxHill",
      "title": "Convert linear effect to Emax-Hill effect",
      "topics": [
        "convertEmaxHill"
      ]
    },
    {
      "page": "convertKinR0",
      "title": "Convert a kin/kout indirect response model to R0 and kout",
      "concept": [
        "Indirect response"
      ],
      "topics": [
        "convertKinR0"
      ]
    },
    {
      "page": "convertLogLin",
      "title": "Converts a linear effect to a log-linear effect",
      "concept": [
        "PD"
      ],
      "topics": [
        "convertLogLin"
      ]
    },
    {
      "page": "convertMM",
      "title": "Convert models from linear elimination to Michaelis-Menten elimination",
      "topics": [
        "convertMM"
      ]
    },
    {
      "page": "convertQuad",
      "title": "Convert linear elimination to quadratic elimination",
      "concept": [
        "PD"
      ],
      "topics": [
        "convertQuad"
      ]
    },
    {
      "page": "createMarkovModel",
      "title": "Create a Markov model for `nlmixr2`",
      "concept": [
        "Markov models"
      ],
      "topics": [
        "createMarkovModel"
      ]
    },
    {
      "page": "createMarkovModelDataset",
      "title": "Create a Markov model dataset for use in estimating Markov models",
      "concept": [
        "Markov models"
      ],
      "topics": [
        "createMarkovModelDataset",
        "createMarkovModelDataset.data.frame",
        "createMarkovModelDataset.default"
      ]
    },
    {
      "page": "createMarkovModelFromSingleState",
      "title": "Create the parts of a Markov model for transitioning from a single state",
      "concept": [
        "Markov models"
      ],
      "topics": [
        "createMarkovModelFromSingleState"
      ]
    },
    {
      "page": "createMarkovTransitionMatrix",
      "title": "Create a Markov transition matrix with probabilities of transitioning between every state",
      "concept": [
        "Markov models"
      ],
      "topics": [
        "createMarkovTransitionMatrix"
      ]
    },
    {
      "page": "cvToBsv",
      "title": "Convert coefficient of variation (percent) to between-subject variance",
      "topics": [
        "bsvToCv",
        "cvToBsv"
      ]
    },
    {
      "page": "defaultCombine",
      "title": "Default combine strings",
      "topics": [
        "blankCombine",
        "camelCombine",
        "defaultCombine",
        "dotCombine",
        "snakeCombine"
      ]
    },
    {
      "page": "fakeCc",
      "title": "Fake blank Cc for creating PD only models",
      "topics": [
        "fakeCc"
      ]
    },
    {
      "page": "Mann2022Equilibrate",
      "title": "Pre-equilibrate the Mann 2022 respiratory-physiology states",
      "topics": [
        "Mann2022Equilibrate"
      ]
    },
    {
      "page": "modeldb",
      "title": "Model library for nlmixr2",
      "topics": [
        "modeldb"
      ]
    },
    {
      "page": "modellib",
      "title": "Get the model from the model library",
      "topics": [
        "modellib"
      ]
    },
    {
      "page": "ncaComparisonTable",
      "title": "Build a side-by-side NCA comparison table (simulated vs. reference)",
      "topics": [
        "ncaComparisonTable"
      ]
    },
    {
      "page": "ncaParamLabel",
      "title": "Map PKNCA parameter codes to friendly human-readable labels",
      "topics": [
        "ncaParamLabel"
      ]
    },
    {
      "page": "pkTrans",
      "title": "Change the transformation type for PK models",
      "topics": [
        "pkTrans"
      ]
    },
    {
      "page": "readModelDb",
      "title": "Read a model from the nlmixr2 model database",
      "topics": [
        "readModelDb"
      ]
    },
    {
      "page": "removeDepot",
      "title": "To convert from first order oral absorption to IV/Intravenous",
      "topics": [
        "removeDepot"
      ]
    },
    {
      "page": "removeLinesAndInis",
      "title": "Removes lines and inis from a model",
      "topics": [
        "removeLinesAndInis"
      ]
    },
    {
      "page": "removeTransit",
      "title": "To remove transit compartments from the model",
      "concept": [
        "absorption"
      ],
      "topics": [
        "removeTransit"
      ]
    },
    {
      "page": "searchReplace",
      "title": "Search within a model to replace part of the model",
      "topics": [
        "searchReplace",
        "searchReplaceHelper"
      ]
    },
    {
      "page": "setCombineType",
      "title": "Change the default combine type for the package",
      "topics": [
        "setCombineType"
      ]
    },
    {
      "page": "simMarkov",
      "title": "Convert nlmixr2 simulations to Markov states",
      "concept": [
        "Markov models"
      ],
      "topics": [
        "simMarkov"
      ]
    },
    {
      "page": "simMarkovId",
      "title": "Simulate a Markov model broken down by ID",
      "concept": [
        "Markov models"
      ],
      "topics": [
        "simMarkovId"
      ]
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