{
  "_id": "6a227beacd65a98ecbd4e9e1",
  "Package": "nlmixr2",
  "Title": "Nonlinear Mixed Effects Models in Population PK/PD",
  "Version": "6.0.0",
  "Authors@R": "c(person(\"Matthew\",\"Fidler\", role = c(\"aut\", \"cre\"), email = \"matthew.fidler@gmail.com\", comment=c(ORCID=\"0000-0001-8538-6691\")),\nperson(\"Anne\", \"Keunecke\", role=\"ctb\"),\nperson(\"Rik\", \"Schoemaker\", role = \"ctb\", email = \"rik.schoemaker@occams.com\", comment=c(ORCID=\"0000-0002-7538-3005\")),\nperson(\"Justin\", \"Wilkins\", role = \"ctb\", email = \"justin.wilkins@occams.com\", comment=c(ORCID=\"0000-0002-7099-9396\")),\nperson(\"Wenping\", \"Wang\", role = \"ctb\", email = \"wwang8198@gmail.com\"),\nperson(\"Mirjam\",\"Trame\", role = \"ctb\", email=\"mirjam.trame@gmail.com\"),\nperson(\"John\", \"Harrold\", role=\"ctb\", email=\"john.m.harrold@gmail.com\"),\nperson(\"Bill\", \"Denney\", email=\"wdenney@humanpredictions.com\", role=\"ctb\", comment=c(ORCID=\"0000-0002-5759-428X\")),\nperson(\"Theodoros\", \"Papathanasiou\",  role=\"ctb\"),\nperson(\"Richard\", \"Hooijmaijers\", email = \"richardhooijmaijers@gmail.com\", role = \"ctb\"),\nperson(\"Michael Wayne\", \"Kearney\", email = \"kearneymw@missouri.edu\", role = \"ctb\",comment = c(ORCID = \"0000-0002-0730-4694\")))",
  "Description": "Fit and compare nonlinear mixed-effects models in\ndifferential equations with flexible dosing information\ncommonly seen in pharmacokinetics and pharmacodynamics\n(Almquist, Leander, and Jirstrand 2015\n<doi:10.1007/s10928-015-9409-1>). Differential equation solving\nis by compiled C code provided in the 'rxode2' package (Wang,\nHallow, and James 2015 <doi:10.1002/psp4.12052>).",
  "License": "GPL (>= 3)",
  "Encoding": "UTF-8",
  "Roxygen": "list(markdown = TRUE)",
  "RoxygenNote": "7.3.2",
  "BugReports": "https://github.com/nlmixr2/nlmixr2/issues/",
  "URL": "https://nlmixr2.org/, https://github.com/nlmixr2/nlmixr2/",
  "Config/pak/sysreqs": "cmake libgmp3-dev make libicu-dev libjpeg-dev\nlibpng-dev libuv1-dev libxml2-dev libmpfr-dev libssl-dev\nlibx11-dev zlib1g-dev",
  "Repository": "https://nlmixr2.r-universe.dev",
  "Date/Publication": "2026-05-22 00:44:43 UTC",
  "RemoteUrl": "https://github.com/nlmixr2/nlmixr2",
  "RemoteRef": "HEAD",
  "RemoteSha": "f8bc49795d54356e63ec2ca23d5e17db26c0ee36",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-06-05 07:19:21 UTC",
    "User": "root"
  },
  "Author": "Matthew Fidler [aut, cre] (ORCID:\n<https://orcid.org/0000-0001-8538-6691>),\nAnne Keunecke [ctb],\nRik Schoemaker [ctb] (ORCID: <https://orcid.org/0000-0002-7538-3005>),\nJustin Wilkins [ctb] (ORCID: <https://orcid.org/0000-0002-7099-9396>),\nWenping Wang [ctb],\nMirjam Trame [ctb],\nJohn Harrold [ctb],\nBill Denney [ctb] (ORCID: <https://orcid.org/0000-0002-5759-428X>),\nTheodoros Papathanasiou [ctb],\nRichard Hooijmaijers [ctb],\nMichael Wayne Kearney [ctb] (ORCID:\n<https://orcid.org/0000-0002-0730-4694>)",
  "Maintainer": "Matthew Fidler <matthew.fidler@gmail.com>",
  "MD5sum": "17a33762d481f15bb653200ffdafd016",
  "_user": "nlmixr2",
  "_type": "src",
  "_file": "nlmixr2_6.0.0.tar.gz",
  "_fileid": "ef79c0a0949fcc4a891528dffd62044effe34c218175d4170943e477e41080d0",
  "_filesize": 1269982,
  "_sha256": "ef79c0a0949fcc4a891528dffd62044effe34c218175d4170943e477e41080d0",
  "_created": "2026-06-05T07:19:21.000Z",
  "_published": "2026-06-05T07:34:02.784Z",
  "_distro": "noble",
  "_jobs": [
    {
      "job": 79682287779,
      "time": 171,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "FAIL",
      "artifact": ""
    },
    {
      "job": 79682287877,
      "time": 195,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7431026211"
    },
    {
      "job": 79682287809,
      "time": 124,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "7431187308"
    },
    {
      "job": 79682287796,
      "time": 107,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7431208969"
    },
    {
      "job": 79681759839,
      "time": 241,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7430974803"
    },
    {
      "job": 79682287785,
      "time": 179,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7431021943"
    },
    {
      "job": 79682287820,
      "time": 173,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "7431020479"
    },
    {
      "job": 79682287801,
      "time": 166,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "7431018946"
    },
    {
      "job": 79682287787,
      "time": 140,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7431012249"
    }
  ],
  "_buildurl": "https://github.com/r-universe/nlmixr2/actions/runs/27001161820",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/nlmixr2/nlmixr2",
  "_commit": {
    "id": "f8bc49795d54356e63ec2ca23d5e17db26c0ee36",
    "author": "Matthew L. Fidler <matthew.fidler@gmail.com>",
    "committer": "Matthew L. Fidler <matthew.fidler@gmail.com>",
    "message": "Update news\n",
    "time": 1779410683
  },
  "_maintainer": {
    "name": "Matthew Fidler",
    "email": "matthew.fidler@gmail.com",
    "login": "mattfidler",
    "description": "Also a Novartis employee;  Can reach me at my Novartis email: matt.fidler@novartis.com",
    "uuid": 514778,
    "orcid": "0000-0001-8538-6691"
  },
  "_registered": true,
  "_dependencies": [
    {
      "package": "clisymbols",
      "role": "Imports"
    },
    {
      "package": "cli",
      "version": ">= 1.0.0",
      "role": "Imports"
    },
    {
      "package": "crayon",
      "version": ">= 1.3.4",
      "role": "Imports"
    },
    {
      "package": "dplyr",
      "version": ">= 0.7.4",
      "role": "Imports"
    },
    {
      "package": "purrr",
      "version": ">= 0.2.4",
      "role": "Imports"
    },
    {
      "package": "rstudioapi",
      "version": ">= 0.7",
      "role": "Imports"
    },
    {
      "package": "nlmixr2est",
      "version": ">= 5.0.0",
      "role": "Imports"
    },
    {
      "package": "nlmixr2extra",
      "version": ">= 5.0.0",
      "role": "Imports"
    },
    {
      "package": "rxode2",
      "version": ">= 5.0.0",
      "role": "Imports"
    },
    {
      "package": "lotri",
      "version": ">= 0.4.3",
      "role": "Imports"
    },
    {
      "package": "nlmixr2plot",
      "version": ">= 5.0.0",
      "role": "Imports"
    },
    {
      "package": "tibble",
      "role": "Imports"
    },
    {
      "package": "magrittr",
      "role": "Imports"
    },
    {
      "package": "rmarkdown",
      "role": "Suggests"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "devtools",
      "role": "Suggests"
    },
    {
      "package": "ggplot2",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "role": "Suggests"
    },
    {
      "package": "n1qn1",
      "role": "Suggests"
    },
    {
      "package": "withr",
      "role": "Suggests"
    }
  ],
  "_owner": "nlmixr2",
  "_selfowned": true,
  "_usedby": 2,
  "_updates": [
    {
      "week": "2025-27",
      "n": 1
    },
    {
      "week": "2025-28",
      "n": 1
    },
    {
      "week": "2025-29",
      "n": 2
    },
    {
      "week": "2025-35",
      "n": 3
    },
    {
      "week": "2025-48",
      "n": 2
    },
    {
      "week": "2026-04",
      "n": 1
    },
    {
      "week": "2026-17",
      "n": 1
    },
    {
      "week": "2026-21",
      "n": 2
    }
  ],
  "_tags": [
    {
      "name": "v4.0.0",
      "date": "2025-07-17"
    },
    {
      "name": "v4.0.1",
      "date": "2025-08-29"
    },
    {
      "name": "v5.0.0",
      "date": "2025-11-30"
    }
  ],
  "_stars": 89,
  "_contributors": [
    {
      "user": "mattfidler",
      "count": 273,
      "uuid": 514778
    },
    {
      "user": "billdenney",
      "count": 67,
      "uuid": 10359931
    },
    {
      "user": "kestrel99",
      "count": 8,
      "uuid": 9568350
    },
    {
      "user": "huijuanxupmx",
      "count": 1,
      "uuid": 98488016
    },
    {
      "user": "john-harrold",
      "count": 1,
      "uuid": 3170004
    },
    {
      "user": "leovuong",
      "count": 1,
      "uuid": 92429953
    }
  ],
  "_userbio": {
    "uuid": 94710774,
    "type": "organization",
    "name": "nlmixr2"
  },
  "_downloads": {
    "count": 1568,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/nlmixr2"
  },
  "_devurl": "https://github.com/nlmixr2/nlmixr2",
  "_pkgdown": "https://nlmixr2.org/",
  "_searchresults": 249,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/nlmixr2.html",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/nlmixr2/nlmixr2",
  "_realowner": "nlmixr2",
  "_cranurl": true,
  "_releases": [
    {
      "version": "2.0.6",
      "date": "2022-05-24"
    },
    {
      "version": "2.0.7",
      "date": "2022-06-27"
    },
    {
      "version": "2.0.8",
      "date": "2022-10-23"
    },
    {
      "version": "2.0.9",
      "date": "2023-02-21"
    },
    {
      "version": "2.1.0",
      "date": "2024-01-09"
    },
    {
      "version": "2.1.1",
      "date": "2024-02-01"
    },
    {
      "version": "2.1.2",
      "date": "2024-05-30"
    },
    {
      "version": "3.0.0",
      "date": "2024-09-18"
    },
    {
      "version": "3.0.1",
      "date": "2024-10-28"
    },
    {
      "version": "3.0.2",
      "date": "2025-02-20"
    },
    {
      "version": "4.0.0",
      "date": "2025-07-17"
    },
    {
      "version": "4.0.1",
      "date": "2025-08-29"
    },
    {
      "version": "5.0.0",
      "date": "2025-11-30"
    }
  ],
  "_exports": [
    ".nlmixr2attach",
    "nlmixr2CheckInstall",
    "nlmixr2conflicts",
    "nlmixr2deps",
    "nlmixr2packages",
    "nlmixr2update"
  ],
  "_help": [
    {
      "page": "nlmixr2CheckInstall",
      "title": "Check your nlmixr2 installation for potential issues",
      "topics": [
        "nlmixr2CheckInstall"
      ]
    },
    {
      "page": "nlmixr2conflicts",
      "title": "Conflicts between the nlmixr2 and other packages",
      "topics": [
        "nlmixr2conflicts"
      ]
    },
    {
      "page": "nlmixr2deps",
      "title": "List all nlmixr2 dependencies",
      "topics": [
        "nlmixr2deps"
      ]
    },
    {
      "page": "nlmixr2packages",
      "title": "List all packages in the nlmixr2",
      "topics": [
        "nlmixr2packages"
      ]
    },
    {
      "page": "nlmixr2update",
      "title": "Update nlmixr2 packages",
      "topics": [
        "nlmixr2update"
      ]
    }
  ],
  "_pkglogo": "https://github.com/nlmixr2/nlmixr2/raw/HEAD/logo.png",
  "_readme": "https://github.com/nlmixr2/nlmixr2/raw/HEAD/README.md",
  "_rundeps": [
    "armadillo4r",
    "askpass",
    "assertthat",
    "backports",
    "base64enc",
    "BH",
    "binom",
    "bit",
    "bit64",
    "bitops",
    "boot",
    "bslib",
    "cachem",
    "cellranger",
    "checkmate",
    "class",
    "cli",
    "clipr",
    "clisymbols",
    "cluster",
    "colorspace",
    "commonmark",
    "cpp11",
    "cpp4r",
    "crayon",
    "curl",
    "data.table",
    "Deriv",
    "desc",
    "DescTools",
    "digest",
    "dparser",
    "dplyr",
    "e1071",
    "evaluate",
    "Exact",
    "expm",
    "farver",
    "fastmap",
    "fontawesome",
    "forcats",
    "foreign",
    "Formula",
    "fs",
    "generics",
    "ggplot2",
    "ggtext",
    "gld",
    "glue",
    "gridExtra",
    "gridtext",
    "gtable",
    "haven",
    "highr",
    "Hmisc",
    "hms",
    "htmlTable",
    "htmltools",
    "htmlwidgets",
    "httr",
    "inline",
    "isoband",
    "jpeg",
    "jquerylib",
    "jsonlite",
    "knitr",
    "labeling",
    "lattice",
    "lbfgsb3c",
    "lifecycle",
    "litedown",
    "lmom",
    "lotri",
    "magrittr",
    "markdown",
    "MASS",
    "Matrix",
    "memoise",
    "mime",
    "minpack.lm",
    "minqa",
    "mvtnorm",
    "n1qn1",
    "nlme",
    "nlmixr2data",
    "nlmixr2est",
    "nlmixr2extra",
    "nlmixr2plot",
    "nnet",
    "numDeriv",
    "openssl",
    "pander",
    "pillar",
    "pkgconfig",
    "png",
    "PreciseSums",
    "prettyunits",
    "progress",
    "proxy",
    "purrr",
    "qs2",
    "R6",
    "rappdirs",
    "RColorBrewer",
    "Rcpp",
    "RcppArmadillo",
    "RcppEigen",
    "RcppParallel",
    "RCurl",
    "readr",
    "readxl",
    "rematch",
    "rex",
    "rlang",
    "rmarkdown",
    "rootSolve",
    "rpart",
    "rstudioapi",
    "rxode2",
    "rxode2ll",
    "S7",
    "sass",
    "scales",
    "sitmo",
    "StanHeaders",
    "stringfish",
    "stringi",
    "stringr",
    "symengine",
    "sys",
    "tibble",
    "tidyr",
    "tidyselect",
    "tinytex",
    "tzdb",
    "utf8",
    "vctrs",
    "viridisLite",
    "vroom",
    "withr",
    "xfun",
    "xgxr",
    "xml2",
    "yaml"
  ],
  "_score": 8.620116658136695,
  "_indexed": true,
  "_nocasepkg": "nlmixr2",
  "_universes": [
    "nlmixr2",
    "mattfidler"
  ],
  "_binaries": [
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "6.0.0",
      "date": "2026-06-05T07:22:20.000Z",
      "distro": "noble",
      "commit": "f8bc49795d54356e63ec2ca23d5e17db26c0ee36",
      "fileid": "a953235c5c1408107ea622458b20ad181ff71870dec15f9fb2208ec6efcf0a06",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/nlmixr2/actions/runs/27001161820"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "6.0.0",
      "date": "2026-06-05T07:32:01.000Z",
      "commit": "f8bc49795d54356e63ec2ca23d5e17db26c0ee36",
      "fileid": "26991043ee011bf8434c03b8820e794de422e806a9b8f31d95a389667928d395",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/nlmixr2/actions/runs/27001161820"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "6.0.0",
      "date": "2026-06-05T07:33:15.000Z",
      "commit": "f8bc49795d54356e63ec2ca23d5e17db26c0ee36",
      "fileid": "71652adc976c73f2e806cbacf588aab5d87ea58bc161fe1cfcbd511f06f96bf2",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/nlmixr2/actions/runs/27001161820"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "6.0.0",
      "date": "2026-06-05T07:22:34.000Z",
      "commit": "f8bc49795d54356e63ec2ca23d5e17db26c0ee36",
      "fileid": "5b5385ea947e5a29f60a5994e50fb309d07baa9d5f649f683eb4cc51c0e8a0ef",
      "status": "success",
      "buildurl": "https://github.com/r-universe/nlmixr2/actions/runs/27001161820"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "6.0.0",
      "date": "2026-06-05T07:21:41.000Z",
      "commit": "f8bc49795d54356e63ec2ca23d5e17db26c0ee36",
      "fileid": "043580d32d7f72121128653967db803801d284d4b9da122b7352ad7e91403a28",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/nlmixr2/actions/runs/27001161820"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "6.0.0",
      "date": "2026-06-05T07:21:21.000Z",
      "commit": "f8bc49795d54356e63ec2ca23d5e17db26c0ee36",
      "fileid": "e9f8c051c2193d03338b1feee5675633faab9c8faa072f887d640705875cf13e",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/nlmixr2/actions/runs/27001161820"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "6.0.0",
      "date": "2026-06-05T07:21:04.000Z",
      "commit": "f8bc49795d54356e63ec2ca23d5e17db26c0ee36",
      "fileid": "2e3609cdb1832ab2e453d0dcd7181aa4fdd02899abc6eb3fb3b056cfba722e23",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/nlmixr2/actions/runs/27001161820"
    }
  ]
}