{
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  "Type": "Package",
  "Title": "Use 'nlmixr2' to Interact with Open Source and Commercial\nSoftware",
  "Version": "0.1.12.9000",
  "Authors@R": "c(person(\"Matthew\",\"Fidler\", role = c(\"aut\", \"cre\"), email = \"matthew.fidler@gmail.com\", comment=c(ORCID=\"0000-0001-8538-6691\")),\nperson(\"Bill\", \"Denney\", email=\"wdenney@humanpredictions.com\", role=\"aut\", comment=c(ORCID=\"0000-0002-5759-428X\")),\nperson(\"Theodoros\", \"Papathanasiou\",  role=\"ctb\"),\nperson(\"Nook\", \"Fulloption\", role=\"ctb\", comment=\"goldfish art\"))",
  "Description": "Run other estimation and simulation software via the\n'nlmixr2' (Fidler et al (2019) <doi:10.1002/psp4.12445>)\ninterface including 'PKNCA', 'NONMEM' and 'Monolix'. It also\nconverts 'nlmixr2'/'rxode2' models to 'PopED' optimal design\ndatabases (Fidler et al (2024) <doi:10.70534/XUMG6226>). While\nnot required, you can get/install the 'lixoftConnectors'\npackage in the 'Monolix' installation, as described at the\nfollowing url\n<https://monolixsuite.slp-software.com/r-functions/2024R1/installation-and-initialization>.\nWhen 'lixoftConnectors' is available, 'Monolix' can be run\ndirectly instead of setting up command line usage.",
  "License": "GPL (>= 3)",
  "URL": "https://nlmixr2.github.io/babelmixr2/,\nhttps://github.com/nlmixr2/babelmixr2/",
  "NeedsCompilation": "yes",
  "Encoding": "UTF-8",
  "Roxygen": "list(markdown = TRUE)",
  "Config/testthat/edition": "3",
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  "Repository": "https://nlmixr2.r-universe.dev",
  "Date/Publication": "2026-10-16 18:50:21 UTC",
  "RemoteUrl": "https://github.com/nlmixr2/babelmixr2",
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  "Packaged": {
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  "Author": "Matthew Fidler [aut, cre] (ORCID:\n<https://orcid.org/0000-0001-8538-6691>),\nBill Denney [aut] (ORCID: <https://orcid.org/0000-0002-5759-428X>),\nTheodoros Papathanasiou [ctb],\nNook Fulloption [ctb] (goldfish art)",
  "Maintainer": "Matthew Fidler <matthew.fidler@gmail.com>",
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  "_created": "2026-10-16T21:29:42.000Z",
  "_published": "2026-10-16T21:44:16.153Z",
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    ".minfo",
    ".nlmerCurrentFormula",
    ".nlmerNlmerFun",
    ".nlmixrNlmeFun",
    ".popedCluster",
    ".popedF",
    ".popedFree",
    ".popedRxRunSetup",
    ".popedSolveIdME",
    ".popedSolveIdME2",
    ".popedW",
    ".pseudoOptimF",
    "%>%",
    "ACF",
    "add.dosing",
    "add.sampling",
    "addCwres",
    "addNpde",
    "addTable",
    "as.monolix",
    "as.nlmixr",
    "as.nlmixr2",
    "as.nonmem",
    "as.nonmem2rx",
    "augPred",
    "babel.poped.database",
    "babelBpopIdx",
    "bblDatToMonolix",
    "bblDatToMrgsolve",
    "bblDatToNonmem",
    "bblDatToPknca",
    "bblDatToRxode",
    "bobyqaControl",
    "bootplot",
    "bootstrapFit",
    "et",
    "etExpand",
    "eventTable",
    "expit",
    "fixed.effects",
    "fixef",
    "fmeMcmcControl",
    "foceiControl",
    "geom_amt",
    "geom_cens",
    "getData",
    "getStandardColNames",
    "getValidNlmixrCtl",
    "getVarCov",
    "groupedData",
    "ini",
    "ini<-",
    "iterPrintControl",
    "lbfgsb3cControl",
    "logit",
    "lotri",
    "mlxtran",
    "model",
    "model<-",
    "modelUnitConversion",
    "monolix2rx",
    "monolixControl",
    "n1qn1Control",
    "newuoaControl",
    "nlmControl",
    "nlme",
    "nlmeControl",
    "nlmerControl",
    "nlminbControl",
    "nlmixr",
    "nlmixr2",
    "nlmixr2AllEst",
    "nlmixr2Est",
    "nlmixr2NlmeControl",
    "nlmixr2NlmerControl",
    "nlsControl",
    "nmcov",
    "nmext",
    "nmGetDistributionMonolixLines",
    "nmGetDistributionNonmemLines",
    "nminfo",
    "nmObjGetControl",
    "nmObjGetFoceiControl",
    "nmObjHandleControlObject",
    "nmtab",
    "nmxml",
    "nonmem2rx",
    "nonmemControl",
    "optimControl",
    "pdBlocked",
    "pdCompSymm",
    "pdConstruct",
    "pdDiag",
    "pdFactor",
    "pdIdent",
    "pdLogChol",
    "pdMat",
    "pdMatrix",
    "pdNatural",
    "pdSymm",
    "pkncaControl",
    "popedControl",
    "popedGetMultipleEndpointModelingTimes",
    "popedMultipleEndpointIndexDataFrame",
    "popedMultipleEndpointParam",
    "popedMultipleEndpointResetTimeIndex",
    "preconditionFit",
    "probit",
    "probitInv",
    "profileFixed",
    "profileFixedSingle",
    "profileLlp",
    "pseudoOptimControl",
    "random.effects",
    "ranef",
    "reStruct",
    "rxCat",
    "rxClean",
    "rxControl",
    "rxDerived",
    "rxFun",
    "rxModelVars",
    "rxode",
    "RxODE",
    "rxode2",
    "rxParam",
    "rxParams",
    "rxSetPipingAuto",
    "rxSetSeed",
    "rxSolve",
    "rxToMonolix",
    "rxToNonmem",
    "rxUiGet",
    "saemControl",
    "saemixControl",
    "setOfv",
    "simplifyUnit",
    "stat_amt",
    "stat_cens",
    "tableControl",
    "traceplot",
    "uobyqaControl",
    "varComb",
    "varConstPower",
    "VarCorr",
    "varExp",
    "varFixed",
    "varFunc",
    "varIdent",
    "varPower",
    "varWeights",
    "vpcCens",
    "vpcCensTad",
    "vpcPlot",
    "vpcPlotTad",
    "vpcSim"
  ],
  "_help": [
    {
      "page": "dot-nlmerNlmerFun",
      "title": "Surrogate gradient function for lme4::nlmer",
      "topics": [
        ".nlmerNlmerFun"
      ]
    },
    {
      "page": "dot-setupPopEDdatabase",
      "title": "Setup the poped database",
      "topics": [
        ".setupPopEDdatabase"
      ]
    },
    {
      "page": "as.nlmixr2",
      "title": "Convert an object to a nlmixr2 fit object",
      "topics": [
        "as.nlmixr",
        "as.nlmixr2"
      ]
    },
    {
      "page": "as.nonmem",
      "title": "Convert an nlmixr2 model to a NONMEM control stream or Monolix project",
      "topics": [
        "as.monolix",
        "as.nonmem"
      ]
    },
    {
      "page": "babel.poped.database",
      "title": "Expand a babelmixr2 PopED database",
      "topics": [
        "babel.poped.database"
      ]
    },
    {
      "page": "babelBpopIdx",
      "title": "Get the bpop_idx by variable name for a poped database created by 'babelmixr2'",
      "topics": [
        "babelBpopIdx"
      ]
    },
    {
      "page": "bblDatToMonolix",
      "title": "Convert nlmixr2-compatible data to other formats (if possible)",
      "topics": [
        "bblDatToMonolix",
        "bblDatToMrgsolve",
        "bblDatToNonmem",
        "bblDatToPknca",
        "bblDatToRxode"
      ]
    },
    {
      "page": "fmeMcmcControl",
      "title": "Control for fmeMcmc estimation method in nlmixr2",
      "topics": [
        "fmeMcmcControl"
      ]
    },
    {
      "page": "getStandardColNames",
      "title": "Determine standardized rxode2 column names from data",
      "topics": [
        "getStandardColNames"
      ]
    },
    {
      "page": "modelUnitConversion",
      "title": "Unit conversion for pharmacokinetic models",
      "concept": [
        "Unit conversion"
      ],
      "topics": [
        "modelUnitConversion"
      ]
    },
    {
      "page": "monolixControl",
      "title": "Monolix Controller for nlmixr2",
      "topics": [
        "monolixControl"
      ]
    },
    {
      "page": "nlmixr2Est.nlmer",
      "title": "nlmixr2 estimation using lme4::nlmer",
      "topics": [
        "nlmixr2Est.nlmer"
      ]
    },
    {
      "page": "nlmixr2Est.pknca",
      "title": "Estimate starting parameters using PKNCA",
      "topics": [
        "nlmixr2Est.pknca"
      ]
    },
    {
      "page": "nlmixr2NlmerControl",
      "title": "Control for nlmer estimation method in nlmixr2",
      "topics": [
        "nlmerControl",
        "nlmixr2NlmerControl"
      ]
    },
    {
      "page": "nonmemControl",
      "title": "NONMEM estimation control",
      "topics": [
        "nonmemControl"
      ]
    },
    {
      "page": "pkncaControl",
      "title": "PKNCA estimation control",
      "topics": [
        "pkncaControl"
      ]
    },
    {
      "page": "popedControl",
      "title": "Control for a PopED design task",
      "topics": [
        "popedControl"
      ]
    },
    {
      "page": "popedGetMultipleEndpointModelingTimes",
      "title": "Get Multiple Endpoint Modeling Times",
      "topics": [
        "popedGetMultipleEndpointModelingTimes",
        "popedMultipleEndpointIndexDataFrame"
      ]
    },
    {
      "page": "popedMultipleEndpointResetTimeIndex",
      "title": "Reset the Global Time Indexer for Multiple Endpoint Modeling",
      "topics": [
        "popedMultipleEndpointResetTimeIndex"
      ]
    },
    {
      "page": "pseudoOptimControl",
      "title": "Control for fmeMcmc estimation method in nlmixr2",
      "topics": [
        "pseudoOptimControl"
      ]
    },
    {
      "page": "rxToMonolix",
      "title": "Convert RxODE syntax to monolix syntax",
      "topics": [
        "rxToMonolix"
      ]
    },
    {
      "page": "rxToNonmem",
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